Kutumizga na Pathogenesis ya Feline Panleucopenia

Kasi palleukopenia wa feline pansoukopenia wakuthandazgika wuli?

Virusi la panleukopenia (FPV) ni virus iyo yili na nthenda yayi (nthemerazi (1}}} pake virus iyo yili na virus, non{{{-} envelopud virus). Non{{-" mavairasi ghakukhozgeka chomene na vinthu vyakuwoneka na makemikolo kuluska mavairasi agho ghali na envulopu. Mavairasi ghambura envulodi ghali na kutentha kuwemi chomene ndipo ghangazizipizga mwambura kusuzga umo vinthu vikuŵira mu m’mimba, kusazgapo asidi wankhongono wa maji gha m’matumbo na nkhongono ya bile yankhongono. Ntheura, kanandi matenda gha mu matumbo ghakupangika na mavairasi agha. Kweniso ŵangapona pa ndondomeko zinyake za matenda ghakuthandazgika. Mukuyowoya mwakudumura, ici cikung’anamura kuti mavairasi agha ghalutilire kuŵa ghamoyo ndiposo ghakuthandazgika mu nyengo zakofya izi. FPV yingakhalako kwa myezi yinandi mu malo gha kuwaro, ndipo nanga nkhujumpha chaka chimoza mu malo ghakwenelera. Padera pa nyengo yakuponoskekera, FPV yili na nkhongono zakulimbana na mphepo ndipo yingapona kwa theka la ora pa nyengo yakutentha comene kuluska 56℃, ndipo moŵa na iodophor vilije nkhongono pa iyo.

Vinyama vinandi

Vinyama ivyo vikuŵa na mphaka vikuŵa chomene, chomenechomene mphaka izo zikupokera katemera yayi panji zikupangika na katemera wakukwana, ndipo mphaka izo zilije nesi. Yakwamba yikasanga yayi chivikiliro chakukwana cha FPV kufuma ku katemera, apo wachiŵiri wakapokera yayi chitetezo cha antibody cha ŵamama (MDA) kufuma ku mkaka wa mama.

Kuŵa na matenda

Amphaka awo ŵali na FPV, chomenechomene awo ŵali na vimanyikwiro vya matenda, ŵangawuskapo poizoni kwizira mu m’mimba, m’mimba, m’mimba, maloŵe, kubokora, na vinyake. Mavairasi ghangawunjika mwaluŵiro mu malo agho ghakhwaskika. Chifukwa chakuti FPV yikuthandazgika chomene, vinyama ivyo vikukhwaskika vingaŵa kuti vichali na matenda nanga ni para munthu wali na nthenda iyo yikukoma chomene. Ntheura, kujipatura panji kunjira mu malo ghanthena uku kukulimbikiskika waka kwa amphaka awo ŵali kupokera katemera makora ndipo ŵapeleka chivikiliro chakukwana ku FPV.

Nthowa yakupinjizga

Vinyama ivyo vikuŵa na nthenda iyi vikukhwaskika chomene na FPV kwizira mu kukhwaskana mwaluŵiro na vinyama ivyo vili na matenda, panji kwizira mu kukhwaskana na mlomo panji kupuma na vyakurya vyakufipirwa, maji ghakumwa, viŵiya, na malo ghakuzingilizga. Kusazgirapo apa, FPV yingatumizgikaso mwakuyimilira kwizira mu placenta na makina kwizira mu arthropods.

Pathogenesis ya virus ya feven paleupopenia

Virusi la panleukopenia (FPV) likupangiska kuti munthu waŵe na matenda. Virusi ili likuthandazgika na fecal -}oral njira, kuwerezgapo pakwamba mu viŵaro vya oropharyngeal ndipo pamanyuma pake kuthandazga pafupifupi viwaro vyose na viremia ya acelular. FPV yikukhumbikwira kuti yiŵeso na maselo gha S -}}phase, agho ghakusangika mu viŵaro vyakugwira ntchito. FPV yikukaka ku transferrin receptors (TFRs) ya maselo gha viwaro agha ndipo yikugwiriskira ncito vipokelero ivi kuti yinjire na maselo ghakukhwaska. Vilonda ivyo vili na misosis yakugwira ntchito ni: m’matumbo crypt epithelium, viwaro vya lymphoid, mnofu wa viwangwa, na vinyake. vikuthemba pa malo agho maselo ghakukhwaskika, viwaro vyakuyana vizamusintha na matenda, ndipo ivi vizamupangiska kuti paŵe vimanyikwiro vyakuyana waka vya chipatala.

FPV yikukhwaska viŵaro vya lymphoid, ivyo vingapangiska kuti maselo ghatozgeke na kuchepa kwa maselo gha thupi. Lymphopenia yingaŵa chifukwa cha lympholysis panji mwambura kumanyikwa chifukwa cha kusamuka kwa lymphocyte mu viŵaro. Mtundu wa viwangwa ukukhwaskika, ndipo kuzgoŵera kwa mavairasi kukuchitika mu maselo gha progenitor, na vyakuchitika pafupifupi pa maselo ghose gha mafupa, ndipo ivi vikupangiska kuti ŵanthu wose awo ŵali na nthenda ya leukocyte ŵapeko, awo ŵakuchemeka "panleukopenia."

Chimanyikwiro cha FPV replation nkhufupikiska villi wa m’matumbo. Virusi ili likuwerezgawerezga mu maselo ghakugaŵa mwaluŵiro mukati mwa crypts gha mu matumbo, ndipo likutimbanizga kuzgoŵera kwa maselo gha mu matumbo, ndipo ivi vikupangiska kuti matumbo ghafupike. Kukura kwa maselo kukukolerana na kusintha kwa maselo gha episolial, na co- kukhwaskika na matenda ghanyake (mwachiyelezgero, feline coronavirus) kungapangiskaso kuti matenda ghaŵe ghanandi. Kuthandazgika kwa FPV panji matenda gha pa nyengo ya kubaba kungakhwaska kukura kwa dongosolo la mitsempha ya pakati. "Mtundu wa aaxical wa feline" ni chifukwa cha matenda gha lytic gha maselo gha Purkinje mu mphaka, ndipo ivi vikupangiska kuti cerebellar yileke kukura.