Pakuyowoya za virus ya nkhumba ya nkhumba gB antibody na gE antibody
Jun 18, 2021
Vilonda vya mitundu yakupambanapambana ya PRV vikupambana chomene. Vinthu vyakupambanapambana ivyo vikupangiska kuti munthu waŵe na suzgo la matenda, nyengo yitali na poizoni, unandi wa poizoni na viwaro vikupambana. PRV yikulaŵilirika na majini ghanandi, kufunyapo kwa majini agha panji ghanandi kungapangiska kuti PRV yiŵe yakukhora. Mapulotini gha mavairasi agho ghakukhwaskana na vilence ghakusazgapo glycoproteins ya mavairasi, virus -}2eded enzymes, na capsid yakusankha -} yakukolerana. Malinga na milimo yakupambanapambana ya glycoproteins mu kuzgoŵezga kwa mavairasi mu maji gha maselo, ghakugaŵika mu non-essential glycoproteins (gC, gE, gE, gG, gL, gM na gN) na glycoproteins yakukhumbikwa (gB, gD, gH, gH, gK na gL) . Pa nkhani ya virusile ya virusi, glycoproteins chomenechomene wakukolerana na PRV kuphatikizgika ku maselo ghakukhumbikwa.
Mu PRV invar ya mitsempha ya trigeminal na nthowa ya mitsempha ya olfactory, glycoprotein gE ni pulotini wakuzirwa. Kufumiskikapo kwa G jini la PRV kungapangiska kuti virusi ya virus vichepeskeke chomene na kuchepeska matenda gha maselo gha neuronal. Ntheura, jini la gE kanandi likufumiskikapo mu katemera wamoyo. Pakuti PRV yikusoŵa gE gene, mtundu wa katemera uwo ukupangika na katemera wamoyo ulije glycoprotein gE, ndipo ntheura ungakhuŵilizga yayi thupi kuti lipangiske ma antibodies ghakuyana waka gha gE mu thupi.
1. Kasi GB antibody mu nkhumba yikwimira antibody iyo yikupangika na katemera wa katemera?
Zgoro la fumbo ili ndakuti: yayi. Pakuti mitundu ya katemera yingapanga ma antibodies gha GB mu nkhumba izo zili na mtundu wa - mtundu, nkhumba zingapangaso ma antibodies gha gB. Chifukwa chakuti envelopu glycoprotein gBB ni glycotein wakukhumbikwa chomene wa PRV, pali envelopu glycoprotein gB gB nga ni katemera wamoyo panji mtundu wa mtundu wa mtundu. Ntheura, kwali ni katemera wamoyo panji mtundu wa mtundu wa mtundu, thupi lizamupangiska thupi kuti lipangiske ma antibodies gha gB. Para mskambo wa nkhumba ngwakukhozga matenda gha pseudorabies gha mu thengere, gB antibody mu thupi lake yikwenera kuti yikusazgako gB antibody iyo yikupangika na katemera na gB antibody iyo yikupangika na matenda gha virus gha mu thengere. Pa nyengo iyo matenda gha mavairasi gha mu thengere ghakupatulika, gB antibody yikwimira antibody iyo yikupangika na katemera wa katemera.
2. Kasi kuŵapo kwa gE ma antibodies mu nkhumba kukulongora kuti nkhumba zikukhwaskika na mavairasi gha mu thengere?
Ŵanthu ŵanandi ŵakung’anamura ivyo ŵasanga pa mayeso, usange ŵakuwona kuti gE antibody, ŵakuwona kuti ni matenda ghakofya gha mavairasi gha mu thengere. Nakuti, ng’anamuro ili ndilo limoza- sided. Kukamba uneneska, gE antibody yikwenera kuŵa antibody iyo yikupangika na matenda gha virus ya mu thengere, kweni kanandi tikuleka kuwona vinthu: para kuseŵa kwakukhwaskika na virus ya mthengere, gE antibody iyo yikupangika yingapelekekaso ku nkhumba zakuyamwa kwizira mu mkaka wa mama, ndipo antibody ya amaternal gE njakukhora chomene. Kanandi nyengo iyi yingatora masabata pafupifupi 10-14.
